|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
MAPK-activated protein kinase II (MK2), downstream kinase of p38 mitogen activated protein kinase (MAPK) p38 MAPK, was unveiled as a promising option for the treatment of AD.
|
31849936 |
2019 |
|
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
After suppressing the p38 pathway, the chondrogenesis can be inhibited, which can be used to guide the treatment of osteoarthritis.
|
31831024 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A detailed mechanistic understanding of how p38 MAPK family members function is urgently warranted for cancer targeted therapy.
|
31828036 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
A detailed mechanistic understanding of how p38 MAPK family members function is urgently warranted for cancer targeted therapy.
|
31828036 |
2019 |
|
Jaundice, Obstructive
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
All these data demonstrated that p38 MAPK-pHsp27 mediates vascular hyporesponsiveness in rats with obstructive jaundice by modulating the expression level of pHsp27 and F-actin, and that inhibition of p38 MAPK signaling could remodel the vascular activity.
|
31810142 |
2020 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sputum protein lysates were analysed for p38 activation in a validation study (n = 24 asthma, n = 8 healthy) by western blotting.
|
31808595 |
2019 |
|
Diabetes Mellitus
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Consequently, the phosphorylation levels of the TNF-α-modulated downstream signaling molecules and P38 mitogen-activated protein kinases (MAPKs) were notably elevated in heart tissues of STZ-induced diabetes.
|
31794124 |
2020 |
|
Diabetes
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Consequently, the phosphorylation levels of the TNF-α-modulated downstream signaling molecules and P38 mitogen-activated protein kinases (MAPKs) were notably elevated in heart tissues of STZ-induced diabetes.
|
31794124 |
2020 |
|
precancerous lesions
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
DFMO was also found to suppress the development of esophageal precancerous lesions in an NMBA-induced rat model; IHC demonstrated p38 α, ERK1/2, and AKT/mTOR/p70S6K pathways to be downregulated in these rats.
|
31793679 |
2020 |
|
beta Thalassemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Oridonin enhances γ‑globin expression in erythroid precursors from patients with β‑thalassemia via activation of p38 MAPK signaling.
|
31789406 |
2020 |
|
beta^+^ Thalassemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Oridonin enhances γ‑globin expression in erythroid precursors from patients with β‑thalassemia via activation of p38 MAPK signaling.
|
31789406 |
2020 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
LncRNA ST8SIA6-AS1 promotes proliferation, migration and invasion in breast cancer through the p38 MAPK ssignalling pathway.
|
31784750 |
2019 |
|
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
LncRNA ST8SIA6-AS1 promotes proliferation, migration and invasion in breast cancer through the p38 MAPK ssignalling pathway.
|
31784750 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
LncRNA ST8SIA6-AS1 promotes proliferation, migration and invasion in breast cancer through the p38 MAPK ssignalling pathway.
|
31784750 |
2019 |
|
Hepatitis
|
0.020 |
Biomarker
|
group |
BEFREE |
The role of alternative p38 activation in liver inflammation is elusive, while classical p38 signaling in hepatocytes plays a role in regulating the induction of cell death in autoimmune-mediated acute liver injury.
|
31780731 |
2019 |
|
Acute hepatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, we found that a mutation of alternative p38 in mice augmented the severity of acute liver inflammation.
|
31780731 |
2019 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our previous data indicated that tanshinone IIA (tan IIA) improves learning and memory in a mouse model of Alzheimer's disease (AD) induced by streptozotocin via restoring cholinergic function, attenuating oxidative stress and blocking p38 MAPK signal pathway activation.
|
31778727 |
2020 |
|
Multiple Myeloma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Knockdown of long non-coding RNA PCAT-1 inhibits myeloma cell growth and drug resistance via p38 and JNK MAPK pathways.
|
31777580 |
2019 |
|
Sepsis
|
0.050 |
Biomarker
|
disease |
BEFREE |
Recombinant CC16 inhibits NLRP3/caspase-1-induced pyroptosis through p38 MAPK and ERK signaling pathways in the brain of a neonatal rat model with sepsis.
|
31775794 |
2019 |
|
Septicemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Recombinant CC16 inhibits NLRP3/caspase-1-induced pyroptosis through p38 MAPK and ERK signaling pathways in the brain of a neonatal rat model with sepsis.
|
31775794 |
2019 |
|
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study verified TXC's efficacy to treat OA in vivo and in vitro and suggests that p38 MAPK pathway-related mechanisms may be involved in TXC's therapeutic effects.
|
31760158 |
2020 |
|
Gastroenteritis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We specifically identified p38 and JNK1, which are the downstream molecules of receptor tyrosine kinases (RTKs) required for efficient TGEV replication, as A9 targets through plaque assays, qRT-PCR and Western blotting assays. p38 and JNK1 inhibitors and RNA interference further showed that the inhibitory activity of A9 against TGEV infection was mainly mediated by the p38 mitogen-activated protein kinase (MAPK) signaling pathway.
|
31751591 |
2020 |
|
Renal fibrosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that CS-N exerts a therapeutic effect on experimental diabetic renal fibrosis by mitigating the EMT and the subsequent ECM deposition with inhibition of p38 and ERK signaling pathways.
|
31739543 |
2019 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transdermal delivery of fluvastatin sodium <i>via</i> tailored spanlastic nanovesicles: mitigated Freund's adjuvant-induced rheumatoid arthritis in rats through suppressing p38 MAPK signaling pathway.
|
31736366 |
2019 |
|
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ultrasound enhanced anti-tumor effect of temozolomide in glioblastoma cells <i>via</i> JNK and p38 pathways.
|
31719901 |
2019 |